Miniaturisation of liquid chromatography in combination with mass spectrometry has several advantages including improvements in
sensitivity, especially at low concentration levels and dramatically reduced solvent consumption and time, compared to conventional HPLC
or UHPLC. LC/MS analysis on a micro-flow scale using 0.1 to 1 mm I.D. column with 1 to several μL/min has the excellent balance of
sensitivity, throughput, and robustness.